For clubbing and night life it could be better to search a room in Trastevere or in Testaccio.
If you are in Rome first of all to visit the Vatican the best choice will be to find your room in the neighborhood of Saint Peter's.
For historical visit you can choose more freely the location of the room but you have to stay in a well connected place.
See you soon for more
For historical visit you can choose more freely the location of the room but you have to stay in a well connected place.
See you soon for more